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In some patients with heart failure who have normal or low blood pressureadditional lowering of systemic blood pressure may occur with lisinoprilThis effect is anticipated and is not usually a reason to discontinue treatmentIf hypotension becomes symptomatica reduction of dose or discontinuation of lisinopril-hydrochlorothiazide may be necessary.

Concomitant treatment with ciclosporin may increase the risk of hyperuricaemia and gout-type complicationsConcomitant treatment with ciclosporin may increase the risk of hyperuricaemia and gout-type complications.

Hydrochlorothiazide should not be used for primary hypertension in pregnant women except in rare situations where no other treatment could be used.

Cough has been reported with the use of ACE inhibitorsCharacteristicallythe cough is non-productivepersistent and resolves after discontinuation of therapyACE inhibitor-induced cough should be considered as part of the differential diagnosis of cough.

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